Radiolabelling methods for complexing AE-emitters to biomolecules (antibodies and peptides) and nanoparticles include radioiodination ( 125I and 123I) or radiometal chelation ( 111In, 67Ga, 99mTc). The Medical Internal Radiation Dose (MIRD) schema may be applied. The radiation dosimetry of AEs considers both organ doses and cellular doses. AEs can also kill targeted cancer cells by damaging the cell membrane, and kill non-targeted cells through a cross-dose or bystander effect. AEs cause DNA damage both directly and indirectly via water radiolysis. ResultsĪEs are most lethal to cancer cells when emitted near the cell nucleus and especially when incorporated into DNA (e.g. In this review, we describe the radiobiological properties of AEs, their radiation dosimetry, radiolabelling methods, and preclinical and clinical studies that have been performed to investigate AEs for cancer treatment. Thus, AE-emitting radiotherapeutic agents have great potential for treatment of cancer. This energy is deposited over nanometre-micrometre distances, resulting in high linear energy transfer (LET) that is potent for causing lethal damage in cancer cells. Auger electrons (AEs) are very low energy electrons that are emitted by radionuclides that decay by electron capture (e.g.
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